Epigenetic regulation of host factors in viral infections.

The EPIVINF project aims to gain a deep understanding of how acute viral infections alter the epigenetic regulation of host factors that are critical for immune control and neurological health. In particular, EPIVINF will address how acute viral infections impact epigenetic control of host proteins that drive virus-associated disease and/or are involved in the antiviral immune response and how such persistent, epigenetic marks are related to long-term disease evolution. The aims of this project are to:
1- understand the extent to which viral infections modify host gene expression through epigenetic dysregulation
2- predict individuals ́ risks for severe disease manifestation
3- identify novel therapeutic targets and
4- develop and improve personalized prophylactic and therapeutic strategies.