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Anti-SARS-CoV-2 antibodies from severe COVID-19 individuals or S2 immunizations do not worsen disease in hamsters
Pedreño-Lopez, N; Tarrés-Freixas, F; Usai, C; Raïch-Regué, D; Benet, S; Ainsua-Enrich, E; Carabelli, J; Pradenas, E; Avila-Nieto, C; Roca, N;...
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Long-term neurocognitive outcomes of SARS-CoV-2 infection in a hamster model
Ruiz-Casas, C; Tarrés-Freixas, F; Roca, N; Pérez, M; Cantero, G; Martín, L; Olvera, A; Ruiz-Riol, M; Brander, C; Usai, C; Vergara-Alert, J;...
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Deep Sequencing Reveals Dual Evolution of SARS-CoV-2: Insights Into Defective Genomes From Wuhan-Hu-1 Variants to Omicron Subvariants
Campos, C; Ibañez-Lligoña, M; Colomer-Castell, S; Gregori, J; Garcia-Cehic, D; Andrés, C; Piñana, M; Gonzalez-Sanchez, A; Rando-Segura, A;...
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The role of innate immune responses against two strains of PEDV (S INDEL and non-S INDEL) in newborn and weaned piglets inoculated by combined orogastric and intranasal routes
Lopez-Figueroa, C; Cano, E; Navarro, N; Perez, M; Lopez, R; Skovgaard, K; Vorsholt, H; Heegaard, P M H; Vergara-Alert, J; Segales, J
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Porcine alveolar macrophages and nasal epithelial cells internalize porcine epidemic diarrhea virus (PEDV) but do not support its replication in vitro
López-Figueroa, C; Carmona-Vicente, N; Cano, E; Navarro, N; Risco, C; Repullés, J; Segalés, J; Vergara-Alert, J
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Comparison of Three Commercial ELISA Kits for Detection of Antibodies Against SARS-CoV-2 in Serum Samples from Different Animal Species
Fernandez-Bastit, Leira; Marfil, Silvia; Pradenas, Edwards; Blanco, Julia; Vergara-Alert, Julia; Segales, Joaquim
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A human-ACE2 knock-in mouse model for SARS-CoV-2 infection recapitulates respiratory disorders but avoids neurological disease associated with the transgenic K18-hACE2 model
Pons-Grifols, Anna; Tarres-Freixas, Ferran; Perez, Monica; Riveira-Munoz, Eva; Raich-Regue, Dalia; Perez-Zsolt, Daniel; Munoz-Basagoiti, Jordana;...
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Subcutaneous administration of an endocrine-mimetic, slow-release protein material reduces the severity of SARS-CoV-2 infection
Parlade, Eloi; Tarres-Freixas, Ferran; Favaro, Marianna T P; Lascorz, Jara; Marquez-Matinez, Merce; Mendoza, Rosa; Corchero, Jose Luis; Cantero,...
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An ACE2-Fc decoy produced in glycoengineered plants neutralizes ancestral and newly emerging SARS-CoV-2 variants and demonstrates therapeutic efficacy in hamsters
Foederl-Hoebenreich, Esther; Izadi, Shiva; Hofacker, Lara; Kienzl, Nikolaus F; Castilho, Alexandra; Strasser, Richard; Tarres-Freixas, Ferran;...
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Targeting eEF1A reprograms translation and uncovers broad-spectrum antivirals against cap or m6A protein synthesis routes
Molina, Elisa Molina; Bech-Serra, Joan Josep; Franco-Trepat, Eloi; Jarne, Ignasi; Perez-Zsolt, Daniel; Badia, Roger; Riveira-Munoz, Eva;...
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Assessment of SARS-CoV-2 exposure in exotic pets in Spain
Cano-Terriza, David; Fernandez-Bastit, Leira; Vergara-Alert, Julia; Vaquez-Calero, Daniel B; Castro-Scholten, Sabrina; Caballero-Gomez, Javier;...
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Proteomics of circulating extracellular vesicles reveals diverse clinical presentations of COVID-19 but fails to identify viral peptides
Gualdron-Lopez, Melisa; Ayllon-Hermida, Alberto; Cortes-Serra, Nuria; Resa-Infante, Patricia; Bech-Serra, Joan Josep; Aparici-Herraiz, Iris;...
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Monitoring SARS-CoV-2 infection in urban and peri-urban wildlife species from Catalonia (Spain)
Fernández-Bastit, L; Montalvo, T; Franco, S; Barahona, L; López-Bejar, M; Carbajal, A; Casas-Díaz, E; Closa-Sebastià, F; Segalés, J;...
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Survey of severe acute respiratory syndrome coronavirus 2 in captive and free-ranging wildlife from Spain
Fernandez-Bastit, L; Cano-Terriza, D; Caballero-Gomez, J; Beato-Benitez, A; Fernandez, A; Garcia-Parraga, D; Domingo, M; Sierra, C; Canales, R;...
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SARS-CoV-2 in Captive Nonhuman Primates, Spain, 2020-2023
Cano-Terriza, David; Beato-Benitez, Adrian; Fernandez-Bastit, Leira; Segales, Joaquim; Vergara-Alert, Julia; Martinez-Nevado, Eva; Carretero, Andrea;...
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Plitidepsin as an Immunomodulator against Respiratory Viral Infections
Losada, Alejandro; Izquierdo-Useros, Nuria; Aviles, Pablo; Vergara-Alert, Julia; Latino, Irene; Segales, Joaquim; Gonzalez, Santiago F; Cuevas,...
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Middle East respiratory coronavirus (MERS-CoV) internalized by llama alveolar macrophages does not result in virus replication or induction of pro-inflammatory cytokines
Rodon, J; Sachse, M; Te, N; Segalés, J; Bensaid, A; Risco, C; Vergara-Alert, J
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Immunization with V987H-stabilized Spike glycoprotein protects K18-hACE2 mice and golden Syrian hamsters upon SARS-CoV-2 infection
Avila-Nieto, C; Vergara-Alert, J; Amengual-Rigo, P; Ainsua-Enrich, E; Brustolin, M; de la Concepción, MLR; Pedreño-Lopez, N; Rodon, J; Urrea, V;...
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Exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the endangered Iberian lynx (Lynx pardinus)
Gómez, JC; Cano-Terriza, D; Segalés, J; Vergara-Alert, J; Zorrilla, I; del Rey, T; Paniagua, J; Gonzálvez, M; Fernández-Bastit, L; Nájera, F;...
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Immunisation efficacy of a stabilised SARS-CoV-2 spike glycoprotein in two geriatric animal models
Usai, C; Ainsua-Enrich, E; Gales, VU; Pradenas, E; Lorca-Oró, C; Tarrés-Freixas, F; Roca, N; Pérez, M; Avila-Nieto, C; de la Concepción, MLR;...
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A monoclonal antibody targeting a large surface of the receptor binding motif shows pan-neutralizing SARS-CoV-2 activity
de Campos-Mata, L; Trinité, B; Modrego, A; Vaquero, ST; Pradenas, E; Pons-Grífols, A; Melero, NR; Carlero, D; Marfil, S; Santiago, C;...
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Clinical, Pathological and Virological Outcomes of Tissue-Homogenate-Derived and Cell-Adapted Strains of Porcine Epidemic Diarrhea Virus (PEDV) in a Neonatal Pig Model
Lopez-Figueroa, C; Cano, E; Navarro, N; Perez-Maillo, M; Pujols, J; Nunez, JI; Vergara-Alert, J; Segales, J; Cao, YC
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Novel Spike-stabilized trimers with improved production protect K18-hACE2 mice and golden Syrian hamsters from the highly pathogenic SARS-CoV-2 Beta variant
Avila-Nieto, C; Vergara-Alert, J; Amengual-Rigo, P; Ainsua-Enrich, E; Brustolin, M; de la Concepción, MLR; Pedreño-Lopez, N; Rodon, J; Urrea, V;...
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Quantification of camelid cytokine mRNA expression in PBMCs by microfluidic qPCR technology
Rodon, J; Te, NG; Ballester, M; Segalés, J; Vergara-Alert, J; Bensaid, A
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Transmission of severe acute respiratory syndrome coronavirus 2 from humans to animals: is there a risk of novel reservoirs?
Fernández-Bastit, L; Vergara-Alert, J; Segalés, J
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Animal models to study the neurological manifestations of the post-COVID-19 condition
Usai, C; Mateu, L; Brander, C; Vergara-Alert, J; Segalés, J
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Beta-Cyclodextrins as affordable antivirals to treat coronavirus infection
Raïch-Regué, D; Tenorio, R; de Castro, IF; Tarrés-Freixas, F; Sachse, M; Perez-Zsolt, D; Muñoz-Basagoiti, J; Fernández-Sánchez, SY; Gallemi, M;...
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Enhanced antiviral immunity and dampened inflammation in llama lymph nodes upon MERS-CoV sensing: bridging innate and adaptive cellular immune responses in camelid reservoirs
Rodon, J; Te, NG; Segalés, J; Vergara-Alert, J; Bensaid, A
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Preclinical evaluation of a COVID-19 vaccine candidate based on a recombinant RBD fusion heterodimer of SARS-CoV-2
Barreiro, A; Prenafeta, A; Bech-Sabat, G; Roca, M; Mur, EP; March, R; González-González, L; Madrenas, L; Corominas, J; Fernández, A; Moros, A;...
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Extended Viral Shedding of MERS-CoV Clade B Virus in Llamas Compared with African Clade C Strain
Rodon, J; Mykytyn, AZ; Te, NG; Okba, NMA; Lamers, MM; Pailler-García, L; Cantero, G; Albulescu, I; Berend-Jan, B; Peiris, M; Bensaid, A;...
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Enhanced replication fitness of MERS-CoV clade B over clade A strains in camelids explains the dominance of clade B strains in the Arabian Peninsula
Te, N; Rodon, J; Pérez, M; Segalés, J; Vergara-Alert, J; Bensaid, A
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Kinetics of immune responses elicited after three mRNA COVID-19 vaccine doses in predominantly antibody-deficient individuals
Ainsua-Enrich, E; Pedreno-Lopez, N; Bracke, C; Avila-Nieto, C; de la Concepcion, MLR; Pradenas, E; Trinite, B; Marfil, S; Miranda, C; Gonzalez, S;...
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Agreement and differential use of laboratory methods for the detection and quantification of SARS-CoV-2 in experimentally infected animals
Usai, C; Pailler-García, L; Lorca-Oró, C; Fernández-Bastit, L; Roca, N; Brustolin, M; Rodon, J; Pérez, M; Cantero, G; Carrillo, J;...
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Heterologous Systemic Prime-Intranasal Boosting Using a Spore SARS-CoV-2 Vaccine Confers Mucosal Immunity and Cross-Reactive Antibodies in Mice as well as Protection in Hamsters
Katsande, PM; Fernández-Bastit, L; Ferreira, WT; Vergara-Alert, J; Hess, M; Lloyd-Jones, K; Hong, HA; Segales, J; Cutting, SM
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and humoral responses against different variants of concern in domestic pet animals and stray cats from North-Eastern Spain
Fernandez-Bastit, L; Marfil, S; Pradenas, E; Valle, R; Roca, N; Rodon, J; Pailler-García, L; Trinité, B; Parera, M; Noguera-Julian, M; Martorell,...
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Evaluation of alpaca tracheal explants as an ex vivo model for the study of Middle East respiratory syndrome coronavirus (MERS-CoV) infection
Te, N; Rodon, J; Creve, R; Perez, M; Segales, J; Vergara-Alert, J; Bensaid, A
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Susceptibility of Domestic Goat (Capra aegagrus hircus) to Experimental Infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) B.1.351/Beta Variant
Fernández-Bastit, L; Roca, N; Romero-Durana, M; Rodon, J; Cantero, G; García, O; López, C; Pérez, M; López, R; Carrillo, J; Izquierdo-Useros, N;...
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Chronological brain lesions after SARS-CoV-2 infection in hACE2-transgenic mice
Vidal, E; López-Figueroa, C; Rodon, J; Pérez, M; Brustolin, M; Cantero, G; Guallar, V; Izquierdo-Useros, N; Carrillo, J; Blanco, J; Clotet, B;...
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Middle East respiratory syndrome coronavirus infection in camelids
Te, N; Ciurkiewicz, M; van den Brand, JMA; Rodon, J; Haverkamp, AK; Vergara-Alert, J; Bensaid, A; Haagmans, BL; Baumgartner, W; Segalés, J
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Chronological brain lesions after SARS-CoV-2 infection in hACE2-transgenic mice
Vidal, Enric; Lopez-Figueroa, Carlos; Rodon, Jordi; Perez, Monica; Brustolin, Marco; Cantero, Guillermo; Guallar, Victor; Izquierdo-Useros, Nuria;...
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Protective efficacy of an RBD-based Middle East respiratory syndrome coronavirus (MERS-CoV) particle vaccine in llamas
Rodon, J; Mykytyn, AZ; Cantero, G; Albulescu, IC; Bosch, BJ; Brix, A; Audonnet, JC; Bensaid, A; Vergara-Alert, J; Haagmans, BL; Segalés, J
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Heterogeneous Infectivity and Pathogenesis of SARS-CoV-2 Variants Beta, Delta and Omicron in Transgenic K18-hACE2 and Wildtype Mice
Tarrés-Freixas, F; Trinité, B; Pons-Grífols, A; Romero-Durana, M; Riveira-Muñoz, E; Avila-Nieto, C; Pérez, M; Garcia-Vidal, E; Perez-Zsolt, D;...
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Heterogeneous Infectivity and Pathogenesis of SARS-CoV-2 Variants Beta, Delta and Omicron in Transgenic K18-hACE2 and Wildtype Mice
Tarres-Freixas, Ferran; Trinite, Benjamin; Pons-Grifols, Anna; Romero-Durana, Miguel; Riveira-Munoz, Eva; Avila-Nieto, Carlos; Perez, Monica;...
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Unraveling the antiviral activity of plitidepsin against SARS-CoV-2 by subcellular and morphological analysis
Sachse, M; Tenorio, R; Castro, IFD; Munoz-Basagoiti, J; Perez-Zsolt, D; Raich-Regu, D; Rodon, J; Losada, A; Avil, P; Cuevas, C; Paredes, R; Segales,...
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Clinical course impacts early kinetics, magnitude, and amplitude of SARS-CoV-2 neutralizing antibodies beyond 1 year after infection
Pradenas, E; Trinité, B; Urrea, V; Marfil, S; Tarres-Freixas, F; Ortiz, R; Rovirosa, C; Rodon, J; Vergara-Alert, J; Segalées, J; Guallar, V;...
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Rapid SARS-CoV-2 Inactivation in a Simulated Hospital Room Using a Mobile and Autonomous Robot Emitting Ultraviolet-C Light
Lorca-Oró, C; Vila, J; Pleguezuelos, P; Vergara-Alert, J; Rodon, J; Majó, N; López, S; Segalés, J; Saldaña-Buesa, F; Visa-Boladeras, M;...
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First Detection of SARS-CoV-2 Delta (B.1.617.2) Variant of Concern in a Dog with Clinical Signs in Spain
Fernandez-Bastit, L; Rodon, J; Pradenas, E; Marfil, S; Trinite, B; Parera, M; Roca, N; Pou, A; Cantero, G; Lorca-Oro, C; Carrillo, J;...
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Monitoring Natural SARS-CoV-2 Infection in Lions (Panthera leo) at the Barcelona Zoo: Viral Dynamics and Host Responses
Fernández-Bellon, H; Rodon, J; Fernández-Bastit, L; Almagro, V; Padilla-Solé, P; Lorca-Oró, C; Valle, R; Roca, N; Grazioli, S; Trogu, T; Bensaid,...
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Critical Presentation of a Severe Acute Respiratory Syndrome Coronavirus 2 Reinfection: A Case Report
Massanella, Marta; Martin-Urda, Anabel; Mateu, Lourdes; Marin, Toni; Aldas, Irene; Riveira-Munoz, Eva; Kipelainen, Athina; Jimenez-Moyano, Esther;...
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Pigs are not susceptible to SARS-CoV-2 infection but are a model for viral immunogenicity studies
Vergara-Alert, J; Rodon, J; Carrillo, J; Te, N; Izquierdo-Useros, N; de la Concepción, MLR; Avila-Nieto, C; Guallar, V; Valencia, A; Cantero, G;...
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Previous SARS-CoV-2 Infection Increases B.1.1.7 Cross-Neutralization by Vaccinated Individuals
Trinité, B; Pradenas, E; Marfil, S; Rovirosa, C; Urrea, V; Tarrés-Freixas, F; Ortiz, R; Rodon, J; Vergara-Alert, J; Segalés, J; Guallar, V;...
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Type I and III IFNs produced by the nasal epithelia and dimmed inflammation are features of alpacas resolving MERS-CoV infection
Te, N; Rodon, J; Ballester, M; Pérez, M; Pailler-García, L; Segalés, J; Vergara-Alert, J; Bensaid, A
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Identification of Plitidepsin as Potent Inhibitor of SARS-CoV-2-Induced Cytopathic Effect After a Drug Repurposing Screen
Rodon, J; Muñoz-Basagoiti, J; Perez-Zsolt, D; Noguera-Julian, M; Paredes, R; Mateu, L; Quiñones, C; Perez, C; Erkizia, I; Blanco, I; Valencia, A;...
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Stable neutralizing antibody levels 6 months after mild and severe COVID-19 episodes
Pradenas, E; Trinité, B; Urrea, V; Marfil, S; Avila-Nieto, C; de la Concepción, MLR; Tarrés-Freixas, F; Pérez-Yanes, S; Rovirosa, C;...
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SARS-CoV-2 infection elicits a rapid neutralizing antibody response that correlates with disease severity
Trinité, B; Tarrés-Freixas, F; Rodon, J; Pradenas, E; Urrea, V; Marfl, S; de la Concepción, MLR; Avila-Nieto, C; Aguilar-Gurrieri, C; Barajas, A;...
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Protection against reinfection with D614-or G614-SARS-CoV-2 isolates in golden Syrian hamster
Brustolin, M; Rodon, J; de la Concepción, MLR; Avila-Nieto, C; Cantero, G; Pérez, M; Te, N; Noguera-Julián, M; Guallar, V; Valencia, A; Roca, N;...
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Cross-neutralization activity against SARS-CoV-2 is present in currently available intravenous immunoglobulins
Díez, JM; Romero, C; Vergara-Alert, J; Belló-Perez, M; Rodon, J; Honrubia, JM; Segalés, J; Sola, I; Enjuanes, L; Gajardo, R
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Animal models for COVID-19
Muñoz-Fontela, C; Dowling, WE; Funnell, SGP; Gsell, PS; Riveros-Balta, AX; Albrecht, RA; Andersen, H; Baric, RS; Carroll, MW; Cavaleri, M; Qin, C;...
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Detection of SARS-CoV-2 in a cat owned by a COVID-19-affected patient in Spain
Segalés, J; Puig, M; Rodon, J; Avila-Nieto, C; Carrillo, J; Cantero, G; Terrón, MT; Cruz, S; Parera, M; Noguera-Julián, M; Izquierdo-Useros, N;...
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Use of the informational spectrum methodology for rapid biological analysis of the novel coronavirus 2019-nCoV: Prediction of potential receptor, natural reservoir, tropism and therapeutic/vaccine target
Veljkovic V; Vergara-Alert J; Segalés J; Paessler S
