{"id":57783,"date":"2016-09-29T11:33:31","date_gmt":"2016-09-29T09:33:31","guid":{"rendered":"https:\/\/www.irta.cat\/noticia\/irta-cresa-participated-in-a-study-that-solved-the-structure-of-an-infectious-prion\/"},"modified":"2024-11-06T09:18:48","modified_gmt":"2024-11-06T08:18:48","slug":"irta-cresa-participated-in-a-study-that-solved-the-structure-of-an-infectious-prion","status":"publish","type":"noticia","link":"https:\/\/www.irta.cat\/en\/noticia\/irta-cresa-participated-in-a-study-that-solved-the-structure-of-an-infectious-prion\/","title":{"rendered":"IRTA-CReSA participated in a study that solved the structure of an infectious prion"},"content":{"rendered":"<div id=\"ctl00_PlaceHolderMain_ctl05__ControlWrapper_RichHtmlField\">\n<p><b><img loading=\"lazy\" decoding=\"async\" class=\"size-large wp-image-10156 alignright\" src=\"https:\/\/www.irta.cat\/wp-content\/uploads\/2023\/01\/structure-prion-4.jpg\" alt=\"\" width=\"380\" height=\"500\" \/><\/b><\/p>\n<div id=\"ctl00_PlaceHolderMain_ctl05__ControlWrapper_RichHtmlField\">\n<p><b><span lang=\"EN-US\">Prions cause diseases such as mad cow disease or Creutzfeldt-Jakob <\/span><\/b><\/p>\n<p><b><\/b><span lang=\"EN-US\">The study, recently published in the prestigious scientific journal PLOS Pathogens, has finally solved the structure of an infectious prion. The data obtained contradict many of the theoretical models of prion structure proposed so far and allow the formulation of the molecular mechanisms existing behind the replication of prions in mammals with transmissible spongiform encephalopathies.<\/span><\/p>\n<p><span lang=\"EN-US\">Prions are unconventional infectious agents causing disease in both humans and animals, such as Creutzfeldt-Jakob disease or mad cow disease. Unlike viruses or bacteria, prions have no genome because they are composed entirely of protein. To understand their behavior and pathogenesis the key is in their structure, the way in which these proteins fold.<\/span><\/p>\n<p><span lang=\"EN-US\">IRTA-CReSA collaborated in this study by helping to demonstrate that the prion that was finally analyzed was, indeed, infectious. This was done through neuropathological and immunohistochemical studies of the brains of mice inoculated with the same purified protein that had been used to determine the structure. These experiments were carried out in the laboratory PRIOCAT located inside the biocontainment level 3 unit of IRTA-CReSA. A laboratory equipped with the necessary biosafety conditions to work with these pathogens.<\/span><\/p>\n<p><span lang=\"EN-US\">For more information you can read about this study entry in the blog CReSA and the city, &#8220;<\/span><a href=\"http:\/\/www.cresa.cat\/blogs\/sociedad\/en\/es-resol-lestructura-dun-prio-infeccios\/\"><span lang=\"EN-US\">Elucidation of the structure of an infectious prion<\/span><\/a><span lang=\"EN-US\">.&#8221;<\/span><\/p>\n<p><b><span lang=\"EN-US\">The study:<\/span><\/b><\/p>\n<p><a href=\"http:\/\/journals.plos.org\/plospathogens\/article?id=10.1371\/journal.ppat.1005835\"><b><i><span lang=\"EN-US\">The Structural Architecture of an Infectious Mammalian Prion Using Electron Cryomicroscopy<\/span><\/i><\/b><\/a><span lang=\"EN-US\"> Ester V\u00e1zquez-Fern\u00e1ndez, Matthijn R. Vos, Pavel Afanasyev, Lino Cebey, Alejandro M. Sevillano, Enric Vidal, Isaac Rosa, Ludovic Renault, Adriana Ramos, Peter J. Peters, Jos\u00e9 Jes\u00fas Fern\u00e1ndez, Marin van Heel, Howard S. Young,Jes\u00fas R. Requena, Holger Wille <b>PLOS Pathogens<\/b> 2016<\/span><\/p>\n<\/div>\n<\/div>\n","protected":false},"featured_media":13406,"template":"","categoria_noticia":[],"etiqueta_filtrar_noticia":[],"class_list":["post-57783","noticia","type-noticia","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\r\n<title>IRTA-CReSA participated in a study that solved the structure of an infectious prion &#187; IRTA<\/title>\r\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\r\n<link rel=\"canonical\" href=\"https:\/\/www.irta.cat\/en\/noticia\/irta-cresa-participated-in-a-study-that-solved-the-structure-of-an-infectious-prion\/\" \/>\r\n<meta property=\"og:locale\" content=\"en_US\" \/>\r\n<meta property=\"og:type\" content=\"article\" \/>\r\n<meta property=\"og:title\" content=\"IRTA-CReSA participated in a study that solved the structure of an infectious prion &#187; IRTA\" \/>\r\n<meta property=\"og:description\" content=\"Prions cause diseases such as mad cow disease or Creutzfeldt-Jakob The study, recently published in the prestigious scientific journal PLOS Pathogens, has finally solved the structure of an infectious prion. The data obtained contradict many of the theoretical models of prion structure proposed so far and allow the formulation of the molecular mechanisms existing behind [&hellip;]\" \/>\r\n<meta property=\"og:url\" content=\"https:\/\/www.irta.cat\/en\/noticia\/irta-cresa-participated-in-a-study-that-solved-the-structure-of-an-infectious-prion\/\" \/>\r\n<meta property=\"og:site_name\" content=\"IRTA\" \/>\r\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/irtacat\" \/>\r\n<meta property=\"article:modified_time\" content=\"2024-11-06T08:18:48+00:00\" \/>\r\n<meta property=\"og:image\" content=\"https:\/\/www.irta.cat\/wp-content\/uploads\/2023\/01\/structure-prion-4.jpg\" \/>\r\n\t<meta property=\"og:image:width\" content=\"758\" \/>\r\n\t<meta property=\"og:image:height\" content=\"997\" \/>\r\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\r\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\r\n<meta name=\"twitter:site\" content=\"@irtacat\" \/>\r\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\r\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.irta.cat\\\/en\\\/noticia\\\/irta-cresa-participated-in-a-study-that-solved-the-structure-of-an-infectious-prion\\\/\",\"url\":\"https:\\\/\\\/www.irta.cat\\\/en\\\/noticia\\\/irta-cresa-participated-in-a-study-that-solved-the-structure-of-an-infectious-prion\\\/\",\"name\":\"IRTA-CReSA participated in a study that solved the structure of an infectious prion &#187; 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