Show side menu

Strategic Science Initiative on Antimicrobial Reduction in Animal Production

The increase in antibiotic resistance and the emergence of new resistance mechanisms that threaten the ability to treat common infectious diseases -such as tuberculosis, pneumonia or sepsis- entail a great socio-economic burden due to the high costs of treatment and, in the specific case of animals, due to the decrease in their productivity.

To avoid a post-antibiotic scenario, IRTA is working intensively on the development of holistic strategies that contribute to eliminate inadequate practices to reduce the risk of zoonotic diseases and offer diagnostic tools and alternative management and treatment strategies (such as new vaccines or development and validation of rapid detection methods).



Related scientific articles:


>> Click here and the bibliographic citations of all related articles will be displayed:


  • Antimicrobial susceptibility testing of porcine bacterial pathogens: Investigating the prospect of testing a representative drug for each antimicrobial family. Antibiotics, 2022, 11, 638. 
    A Vilaró, E Novell, V Enrique-Tarancon, J Balielles, L Migura-García, L Fraile. 
  • Assessment of a novel microalgae-cork based technology for removing antibiotics, pesticides and nitrates from groundwater. Chemosphere. 2022 Aug;301:134777
    Rambaldo, L., Ávila, H., Casas, M. E., Guivernau, M., Viñas, M., Trobajo, R., et al.
  • Assessment of animal diseases caused by bacteria resistant to antimicrobials: kept fish species. EFSA Journal, 2022-02-02. 
    EFSA Panel on Animal Health and Welfare (AHAW); Nielsen, SS et al.
  • Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): antimicrobial-resistant Brachyspira hyodysenteriae in swine. EFSA Journal, 2022-03-15.
    EFSA Panel on Animal Health and Welfare (AHAW); Nielsen, SS et al.
  • Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): antimicrobial-resistant Enterococcus cecorum in poultry. EFSA Journal, 2022-02-25. 
    EFSA Panel on Animal Health and Welfare (AHAW); Nielsen, SS et al.
  • Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): antimicrobial-resistant Enterococcus faecalis in poultry. EFSA Journal, 2022-02-21. 
    EFSA Panel on Animal Health and Welfare (AHAW); Nielsen, SS et al.
  • Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): antimicrobial-resistant Escherichia coli in dogs and cats, horses, swine, poultry, cattle, sheep and goats. EFSA Journal, 2022-05-10. EFSA Panel on Animal Health and Welfare (AHAW); Nielsen, SS et al.
  • Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): antimicrobial-resistant Pseudomonas aeruginosa in dogs and cats. EFSA Journal, 2022-05-03EFSA Panel on Animal Health and Welfare (AHAW); Nielsen, SS et al.
  • Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): antimicrobial-resistant Rhodococcus equi in horses. EFSA Journal, 2022-02-02. EFSA Panel on Animal Health and Welfare (AHAW); Nielsen, SS et al.
  • Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): antimicrobial-resistant Staphylococcus aureus in cattle and horses. EFSA Journal, 2022-05-10. EFSA Panel on Animal Health and Welfare (AHAW); Nielsen, SS et al.
  • Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): antimicrobial-resistant Staphylococcus pseudintermedius in dogs and cats. EFSA Journal, 2022-02-01. EFSA Panel on Animal Health and Welfare (AHAW); Nielsen, SS et al.
  • Exploring the impact of the recombinant Escherichia coli strain on defensins antimicrobial activity: BL21 versus Origami strain Microb Cell Fact. 2022 May 9;21(1):77. doi: 10.1186/s12934-022-01803-7. López-Cano A, Martínez-Miguel M, Guasch J, Ratera I, Arís A, Garcia-Fruitós E.
  • Potential of Oral Nanoparticles Containing Cytokines as Intestinal Mucosal Immunostimulants in Pigs: A Pilot Study. Animals (Basel). 2022 Apr 21;12(9):1075. doi: 10.3390/ani12091075. López-Cano A, Bach A, López-Serrano S, Aragon V, Blanch M, Pastor JJ, Tedó G, Morais S, Garcia-Fruitós E, Arís A.
  • Simulation of feed restriction and fasting: Effects on animal recovery and gastrointestinal permeability in unweaned Angus-Holstein calves. J Dairy Sci. 2022 Mar;105(3):2572-2586. doi: 10.3168/jds.2021-20878. L Pisoni , M Devant, M Blanch, J J Pastor, S Marti.
  • Sow vaccination against virulent Glaesserella parasuis shapes the nasal microbiota of their offspring. Sci Rep (2022) 12:3357. Blanco-Fuertes M, F Correa-Fiz, S Lopez-Serrano, M Sibila, V Aragon.
  • First Report of Streptococcus ruminantium in Wildlife: Phenotypic Differences with a Spanish Domestic Ruminant Isolate Piglet innate immune response to Streptococcus suis colonization is modulated by the virulence of the strain. Vet Res (2021) 52:145. Neila-Ibáñez C, E Pintado, R Velarde, X Fernández Aguilar, E Vidal, V Aragon, ML Abarca.
  • Haemophilus parasuis (Glaesserella parasuis) as a potential driver of molecular mimicry and inflammation in Rheumatoid Arthritis. Frontiers in Medicine (2021) 8:671018. Di Sante G, Gremese E, Tolusso B, Cattani P, Di Mario C, Marchetti S, Alivernini S, Tredicine M, Petricca L, Palucci I, Camponeschi C, Aragon V,  Gambotto A, Ria F, Ferraccioli G.
  • Sow contact is a major driver in the development of the nasal microbiota of piglets. Pathogens (2021) 10(6):697. Obregón-Gutierrez P, V Aragon, F Correa-Fiz.
  • Sow vaccination with a protein fragment against virulent Glaesserella (Haemophilus) parasuis modulates immunity traits in their offspring. Vaccines (2021) 9:534. López-Serrano S, C Neila-Ibáñez, M Costa-Hurtado, Y Mahmmod, J Martínez-Martínez, IJ Galindo-Cardiel, A Darji, F Rodríguez, M Sibila, V Aragon.
  • Altered nasal microbiota composition associated with development of polyserositis by Mycoplasma hyorhinis. Pathogens (2021) 10: 603Blanco-Fuertes M, Correa-Fiz F, Fraile L, Sibila M, V Aragon
  • Molecular characterization of Glaesserella parasuis strains isolated from North America, Europe and Asia by serotyping PCR and LS-PCR. Vet Res (2021) 52:68
    Macedo N, M Gottschalk, K Strutzberg-Minder, C Nguyen Van, L Zhang, G Zou, R Zhou, T Marostica, A Tucker, MJ Clavijo, V Aragon
  • Eurasian griffon vultures carry widespread antimicrobial resistant Salmonella and Campylobacter of public health concern. Science of the Total Environment. 844: 157189
    J. Espunyes, L. Illera, A. Dias-Alves, L. Lobato, M. Puig Ribas, A. Manzanares, T. Ayats, I. Marco, M. Cerdà-Cuéllar. 2022.
  • Antimicrobial resistant Salmonella in chelonians: assessing its potential risk in zoological institutions in Spain. Veterinary Sciences. 9(6):264
    C. Marin, B. Martín-Maldonado, M. Cerdà-Cuéllar, S. Sevilla-Navarro, L. Lorenzo-Rebenaque, et al.
  • Persistent Salmonella problems in slaughterhouses related to clones linked to poultry companies. Poultry Science. 101(8):101968
    C. Marin, M. Cerdà-Cuéllar, S. González-Bodi, L. Lorenzo-Rebenaque, S. Vega.
  • Chicken liver is a potential reservoir of bacteriophages and phage-derived particles containing antibiotic resistance genes. Microbial Biotechnology. DOI: 10.1111/1751-7915.14056. PMID: 35485188
    P. Blanco-Picazo, C. Gómez-Gómez, S. Aguiló-Castillo, D. Fernandez-Orth, M. Cerdà-Cuéllar, M. Muniesa, L. Rodríguez-Rubio
  • Zoonotic Campylobacter spp. and Salmonella spp. carried by wild boars in a metropolitan area: occurrence, antimicrobial susceptibility and public health relevance. Science of the Total Environment. 822: 153444.
    R. Castillo-Contreras, M. Marin, J.R. López-Olvera, T. Ayats, X. Fernandez Aguilar, S. Lavin, G. Mentaberre, M. Cerdà-Cuéllar
  • Maternal supplementation with Bacillus altitudinis spores improves porcine offspring growth performance and carcass weight, British Journal Of Nutrition. 127 (3): 403-420
    Crespo-Piazuelo, D; Gardiner, GE; Ranjitkar, S; Bouwhuis, MA; Ham, R; Phelan, JP; Marsh, A; Lawlor, PG
  • Revealing genomic insights of the unexplored porcine pathogen Actinobacillus pleuropneumoniae using whole genome sequencing. Microbiology Spectrum, 2022 e01185-22DOI: 10.1128/spectrum.01185-22
    J Guitart-Matas, N Gonzalez-Escalona, M Maguire, A Vilaró, J Martinez-Urtaza, L Fraile, L Migura-Garcia
  • The freshwater mussel Unio mancus as a sentinel of faecal bacteria: a study on the retention time of Escherichia coli. Scientific Reports 2022 12:12382
    M Campos, L Lobato-Bailón, R Merciai, O Cabezón, I Torres-Blas, R Araujo, L Migura-Garcia.
  • Skin Multi-Omics-Based Interactome Analysis: Integrating the Tissue and Mucus Exuded Layer for a Comprehensive Understanding of the Teleost Mucosa Functionality as Model of Study. Front. Immunol. 11:613824.
    Reyes-López FE, Ibarz A, Ordóñez-Grande B, Vallejos-Vidal E, Andree KB, Balasch JC, Fernández-Alacid L, Sanahuja I, Sánchez-Nuño S, Firmino JP, Pavez L, Polo J, Tort L and Gisbert E
  • Transmission of similar mcr-1 carrying plasmids among different Escherichia coli lineages isolated from livestock and the farmer. Antibiotics 2021, 10, 313
    J Viñes, A Cuscó, S Napp, J Alvarez, JL Saez-Llorente, M Rosas-Rodareda, O Francino, L Migura-Garcia.
  • Detection of beta-lactam-resistant Escherichia coli and toxigenic Clostridioides difficile strains in wild boars foraging in an anthropization gradient. Animals 2021, 11, 1585.
    Darwich L Seminati, C, Lopez-Olvera JR, Vidal A, Aguirre L, Cerdá M, Garcias B, Valldeperes M, Castillo-Contreras R, Migura-Garcia L et al.
  • Antimicrobial resistance in Pasteurellaceae isolates from Pyrenean Chamois (Rupicapra pyrenaica) and domestic sheep in an Alpine Ecosystem. Animals 2021, 11, Issue 6, 1686
    I Torres-Blas, X Fernández Aguilar, O Cabezón, V Aragon, L Migura-García
  • Prevalence of Salmonella in free-range pigs: risk factors and intestinal microbiota composition. Foods 2021, 10, 1410.
    Garrido V, Migura-García L, Gaitán I, Arrieta-Gisasola A, Martínez-Ballesteros I, Fraile L, Grilló MJ.
  • Stochastic assessment of the economic impact of Streptococcus suis- associated disease in German, Dutch and Spanish swine farms. Front Vet Sci 2021, 8:676002.
    C Neila-Ibáñez, J Casal, I Hennig-Pauka, N Stockhofe-Zurwieden, M Gottschalk, L Migura-Garcia, L Pailler-García, S Napp.
  • Whole genome sequencing and de novo assembly of Staphylococcus pseudintermedius: a pangenome approach to unravelling pathogenesis of canine pyoderma. Vet Dermatol. 32(6):654-663.
    Ferrer L, García-Fonticoba R, Pérez D, Viñes J, Fàbregas N, Madroñero S, Meroni G, Martino PA, Martínez S, Maté ML, Sánchez-Bruni S, Cuscó A, Migura-García L, Francino O.
  • Ad hoc method for the assessment of animal diseases caused by bacteria resistant to antimicrobials. E EFSA Journal, 2021-06-03
    EFSA Panel on Animal Health and Welfare (AHAW); Nielsen, SS et al.
  • Assessment of animal diseases caused by bacteria resistant to antimicrobials: cattle. EFSA Journal, 2021-12-10
    EFSA Panel on Animal Health and Welfare (AHAW); Nielsen, SS et al.
  • Assessment of animal diseases caused by bacteria resistant to antimicrobials: Dogs and cats. EFSA Journal, 2021-06-28
    EFSA Panel on Animal Health and Welfare (AHAW); Nielsen, SS et al.
  • Assessment of animal diseases caused by bacteria resistant to antimicrobials: Horses. EFSA Journal, 2021-12-24
    EFSA Panel on Animal Health and Welfare (AHAW); Nielsen, SS et al.
  • Assessment of animal diseases caused by bacteria resistant to antimicrobials: Poultry. EFSA Journal, 2021-12-24
    EFSA Panel on Animal Health and Welfare (AHAW); Nielsen, SS et al.
  • Assessment of animal diseases caused by bacteria resistant to antimicrobials: rabbits. EFSA Journal, 2021-12-23
    EFSA Panel on Animal Health and Welfare (AHAW); Nielsen, SS et al.
  • Assessment of animal diseases caused by bacteria resistant to antimicrobials: sheep and goats. EFSA Journal, 2021-12-07
    EFSA Panel on Animal Health and Welfare (AHAW); Nielsen, SS et al.
  • Assessment of animal diseases caused by bacteria resistant to antimicrobials: Swine. EFSA Journal, 2021-12-24
    EFSA Panel on Animal Health and Welfare (AHAW); Nielsen, SS et al.
  • Sequence edition of single domains modulates the final immune and antimicrobial potential of a new generation of multidomain recombinant proteins Sci Rep. 2021 Dec 10;11(1):23798. doi: 10.1038/s41598-021-03220-z.
    Roca-Pinilla R, Holani R, López-Cano A, Saubi C, Baltà-Foix R, Cobo ER, Garcia-Fruitós E, Arís A.
  • The Potential of Metalloproteinase-9 Administration to Accelerate Mammary Involution and Boost the Immune System at Dry-Off Animals (Basel). 2021 Nov 30;11(12):3415. doi: 10.3390/ani11123415.
    Parés S, Cano-Garrido O, Bach A, Ferrer-Miralles N, Villaverde A, Garcia-Fruitós E, Arís A.
  • Foraging in the Anthropocene: Feeding plasticity of an opportunistic predator revealed by long term monitoring. Ecological Indicators. 129: 107943.
    J. Ouled-Cheikh, V. Morera-Pujol, A. Bahillo, F. Ramírez, M. Cerdà-Cuéllar, R. Ramos
  • Assessing the role of livestock and sympatric wild ruminants in spreading antimicrobial resistant Campylobacter and Salmonella in alpine ecosystems. BMC Veterinary Research 17(1):79. 
    J. Espunyes, O. Cabezón, A. Dias-Alves, P. Miralles, T. Ayats, M. Cerdà-Cuéllar
  • Occurrence and antimicrobial resistance of zoonotic enteropathogens in gulls from Southern Europe. Science of the Total Environment. 763:143018
    N. Antilles, I. García-Bocanegra, A. Alba-Casals, S. López-Soria, N. Pérez-Méndez, M. Saco, J. González-Solís, M. Cerdà-Cuéllar
  • Characterisation of Salmonella Frintrop isolated from dromedary camels (Camelus dromedarius). Transbound. Emerg. Dis. 68:742–746
    S. Sevilla-Navarro, M. Cerdà-Cuéllar, T. Ayats, J. Jordá, C. Marin, S. Vega
  • Describing variability in pig genes involved in coronavirus infections for a One Health perspective in conservation of animal genetic resources, Scientific Reports. 11 (1): 3359
    Bovo S, Schiavo G, Ribani A, Utzeri VJ, Taurisano V, Ballan M,et al.
  • A Co-Association Network Analysis Reveals Putative Regulators for Health-Related Traits in Pigs, Frontiers In Immunology. 12, 784978
    Crespo-Piazuelo, D; Ramayo-Caldas, Y; Gonzalez-Rodriguez, O; Pascual, M; Quintanilla, R; Ballester, M
  • Leveraging host-genetics and gut microbiota to determine immunocompetence in pigs, Animal Microbiome. 3 (1): 74
    Ramayo-Caldas, Y; Zingaretti, LM; Perez-Pascual, D; Alexandre, PA; Reverter, A; Dalmau, A; Quintanilla, R; Ballester, M
  • Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) prevalence in humans in close contact with animals and measures to reduce on-farm colonisation, Irish Veterinary Journal. 74 (1)
    Crespo-Piazuelo, D; Lawlor, PG
  • Understanding host-microbiota interactions in the commercial piglet around weaning, Scientific Reports. 11 (1): 23488
    Saladrigas-Garcia, M; D’Angelo, M; Ko, HL; Nolis, P; Ramayo-Caldas, Y; Folch, JM; Llonch, P; Sola-Oriol, D; Perez, JF; Martin-Orue, SM
  • A gene co-association network regulating gut microbial communities in a Duroc pig population, Microbiome. 9 (1): 52
    Reverter, Antonio; Ballester, Maria; Alexandre, Pamela A; Marmol-Sanchez, Emilio; Dalmau, Antoni; Quintanilla, Raquel; Ramayo-Caldas, Yuliaxis
  • Fish oil rich in eicosapentaenoic acid and docosahexaenoic acid in sow diets modifies oxylipins and immune indicators in colostrum and milk Animal 15(12):100403
    Eudald Llauradó-Calero, Ignacio Badiola, Antoni Delpino-Rius, Rosil Lizardo, David Torrallardona, Enric Esteve-Garcia, Núria Tous 
  • Feed additives for the control of post-weaning Streptococcus suis disease and the effect on the faecal and nasal microbiota. Scientific Reports (2020) 10(1):20354.
    Correa-Fiz F, C Neila-Ibáñez, S López-Soria, S Napp, B Martinez, L Sobrevia, S Tibble, V Aragon, L Migura-Garcia.
  • Update on Streptococcus suis research and prevention in the era of antimicrobial restriction: 4th International Workshop on S. suis. Pathogens (2020) 9(5):374.
    Segura M, Aragon V, Brockmeier SL, Gebhart C, De Greeff A, Kerdsin A, O’Dea MA, Okura M, Saléry M, Schultsz C, Valentin-Weigand P, Weinert L, Wells JM, Gottschalk M.
  • Update on Glässer’s disease: How to control the disease under restrictive use of antimicrobials. Veterinary Microbiology (2020) 242: 108595
    Costa-Hurtado M, Barba-Vidal E, Maldonado J, V Aragon.
  • Heterogeneity of Moraxella isolates found in the nasal cavities of piglets. BMC Veterinary Research (2020) 16:28
    Lopez-Serrano S, N Galofre-Mila, M Costa-Hurtado, AM Pérez-de-Rozas, V Aragon.
  • Variations in association of nasal microbiota with virulent and non-virulent Strains of Glaesserella (Haemophilus) parasuis in weaning piglets. Veterinary Research (2020) 51:7
    Mahmmod Y, F Correa-Fiz, V Aragon
  • Influenza NG-34 T cell conserved epitope adjuvanted with CAF01 as a possible influenza vaccine candidate. Vet Res. 2020. Apr 20;51(1):57
    Sisteré-Oró M, Pedersen GK, Córdoba L, López-Serrano S, Christensen D, Darji A 
  • Conserved HA-peptides expressed along with flagellin in Trichoplusia ni larvae protects chicken against intranasal H7N1 HPAIV challenge. Vaccine, 2020. 16: 416-422
    Sisteré-Oró M, Martínez-Pulgarín S, Solanes D, Veljkovic V, López-Serrano S, Córdoba L, Cordón I, Escribano JM, Darji A.
  • Comparison of Mycoplasma hyopneumoniae and porcine circovirus 2 commercial vaccines efficacy when applied separate or combined under experimental conditions. Porcine Health Manag. 2020. 6:11.
    Sibila M, Guevara G, Cuadrado R, Pleguezuelos P, Pérez D, Pérez de Rozas A, Huerta E, Llorens A, Valero O, Pérez M, López C, Krejci R, Segalés J.
  • Occurrence and antimicrobial resistance of zoonotic enteropathogens in gulls from southern Europe. Sci Total Environ. 2020 Oct 19:143018
    Antilles N, García-Bocanegra I, Alba-Casals A, López-Soria S, Pérez-Méndez N, Saco M, González-Solís J, Cerdà-Cuéllar M.
  • Foraging at solid urban waste disposal sites as risk factor for cephalosporin and colistin resistant Escherichia coli carriage in white storks (Ciconia ciconia). Frontiers in Micro. July 2020, 11, 1397
    Höfle U, JJ Gonzalez-Lopez, MC Camacho, M Solà-Ginés, A Moreno-Mingorance, JM Hernández, J De La Puente, J Pineda-Pampliega, JI Aguirre, F Torres-Medina, A Ramis, N Majó, J Blas, L Migura-Garcia.
  • mcr-colistin resistance genes mobilized by IncX4, IncHI2 and IncI2 plasmids in Escherichia coli of pigs and white stork in Spain. Frontiers in Micro. January 2020 10, 3072-3072
    L Migura-Garcia, González-López JJ, Martinez-Urtaza J, Aguirre Sánchez JR, Moreno-Mingorance A, Perez de Rozas A, Höfle U, Ramiro Y, Gonzalez-Escalona N.
  • Gut eukaryotic communities in pigs: diversity, composition and host genetics contribution. Animal Microbiome, 2, 18;, 2020
    Yuliaxis Ramayo-Caldas, Francesc Prenafeta-Boldú, Laura M Zingaretti, Olga González-Rodríguez, Antoni Dalmau, Raquel Quintanilla, Maria Ballester.
  • Genome-wide association study for feed efficiency in collective cage-raised rabbits under full and restricted feeding. Animal Genetics, vol. 51(5):799-810, doi: 10.1111/age.12988, 2020
    Sánchez, J.P., Legarra, A., Velasco, M., Piles, M., Sánchez, A., Rafel, O., González, O., Ballester, M.
  • A catalog of microbial genes from the bovine rumen unveils a specialized and diverse biomass-degrading environment. GigaScience, Volume 9, Issue 6, June 2020, giaa057, doi:
    Junhua Li, Huanzi Zhong, Yuliaxis Ramayo-Caldas, Nicolas Terrapon, Vincent Lombard, Gabrielle Potocki-Veronese, Jordi Estellé, Milka Popova, Cécile Martin, Emmanuelle Maguin, Lise Madsen, Karsten Kristiansen, Bernard Henrissat, Stanislav D Ehrlich, Diego P Morgavi.
  • Genetic parameters and associated genomic regions for global immunocompetence and other health-related traits in pigs. Scientific Reports, 10:18462; doi: 10.1038/s41598-020-75417-7, 2020
    M Ballester, Y Ramayo-Caldas, O González-Rodríguez, M Pascual, J Reixach, M Díaz, F Blanc, S López, J Tibau, R Quintanilla
  • Recombinant mammary serum amyloid A3 as a potential strategy to prevent intramammary infections in dairy cows at dry-off. J Dairy Sci. 2020 Apr;103(4):3615-3621. doi: 10.3168/jds.2019-17276
    S Parés, Fr Fàbregas, À Bach, E Garcia-Fruitós, A de Prado and A Arís.
  • Potential of MMP-9 based nanoparticles at optimizing the cow dry period: pulling apart the effects of MMP-9 and nanoparticles. Sci Rep. 10(1):11299
    Gifre-Renom L, Carratalá JV, Parés S, Sánchez-Garcia L, Ferrer-Miralles N, Villaverde A, Bach A, Garcia-Fruitós E, Arís A
  • A new generation of recombinant polypeptides combines multiple protein domains for effective antimicrobial activity. Microbial Cell Factories, 19(1):122
    Roca-Pinilla R, López-Cano A, Saubi C, Garcia-Fruitós E, Arís A
  • Recombinant Protein-Based Nanoparticles: Elucidating their Inflammatory Effects In Vivo and their Potential as a New Therapeutic Format. Pharmaceutics, 12(5):E450
    Gifre-Renom L, Ugarte-Berzal E, Martens E, Boon L, Cano-Garrido O, Martínez-Núñez E, Luque T, Roca-Pinilla R, Conchillo-Solé Ò, Ferrer-Miralles N, Villaverde A, Opdenakker G, Garcia-Fruitós E, Arís A.
  • The growth promoting and immunomodulatory effects of a medicinal plant leaf extract obtained from Salvia officinalis and Lippia citriodora in gilthead seabream (Sparus aurata). Aquaculture, 524, 735291,
    R Salomon, J P. Firmino, F E. Reyes-Lopez, K B. Andree, D Gonzalez-Silvera, M. A Esteban, L Tort, J C. Quintela, J M. Pinilla-Rosas, E Vallejos-Vidal, E Gisbert
  • Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage. Nat Commun. 2019 Mar 8;10(1):1124
    Hendriksen RS, Munk P, Njage P, van Bunnik B, McNally L, Lukjancenko O, Röder T, Nieuwenhuijse D, Pedersen SK, Kjeldgaard J, Kaas RS, Clausen PTLC, Vogt JK, Leekitcharoenphon P, van de Schans MGM, Zuidema T, de Roda Husman AM, Rasmussen S, Petersen B; Global Sewage Surveillance project consortium, Amid C, Cochrane G, Sicheritz-Ponten T, Schmitt H, Alvarez JRM, Aidara-Kane A, Pamp SJ, Lund O, Hald T, Woolhouse M, Koopmans MP, Vigre H, Petersen TN, Aarestrup FM.
  • Haemophilus parasuis VtaA2 is involved in adhesion to extracellular proteins. Veterinary Research (2019) 50:69
    Costa-Hurtado M & Garcia-Rodriguez L, S Lopez-Serrano, V Aragon.
  • Comparative analysis of the fecal microbiota from different species of domesticated and wild suids. Scientific Reports (2019) 9(1):13616
    Correa-Fiz F, M Blanco-Fuertes, MJ Navas, A Lacasta, RP Bishop, N Githaka, C Onzere, MF Le Potier, V Almagro-Delgado, J Martinez, V Aragon, F Rodriguez
  • Antimicrobial removal promotes health and higher bacterial diversity in the nasal microbiota in piglets. Scientific Reports (2019) 9(1):6545
    Correa-Fiz F, JM Gonçalves dos Santos, F Illas, V Aragon.
  • Investigation of Haemophilus parasuis from healthy pigs in China. Veterinary Microbiology (2019) 231:40-44
    Zhang P, C Zhang, V Aragon, X Zhou, M Zou, C Wu, Z Shen.
  • Characterization of Mycoplasma hyopneumoniae strains in vaccinated and non-vaccinated pigs from Spanish slaughterhouses. Veterinary Microbiology (2019) 231: 18-23
    Garza-Moreno L, J Segalés, V Aragon, F Correa-Fiz, M Pieters, M Carmona, R Krejci and M Sibila.
  • DNA vaccine based on conserved HA-peptides induces strong immune response and rapidly clears influenza virus infection from vaccinated pigs. Plos One. 2019. 19(9)
    Sisteré-Oró M, López-Serrano S, Veljkovic V, Pina-Pedrero S, Vergara-Alert J, Córdoba L, Pérez-Maillo M, Pleguezuelos P, Vidal E, Segalés J, Nielsen J, Fomsgaard A, Darji A.
  • Conserved HA-peptide NG34 formulated in pCMV-CTLA4-Ig reduces viral shedding in pigs after a heterosubtypic influenza virus SwH3N2 challenge. Plos One. 2019.19(3)
    Sisteré-Oró M, Vergara-Alert J, Stratmann T, López-Serrano S, Pina-Pedrero S, Córdoba L, Pérez-Maillo M, Pleguezuelos P, Vidal E, Veljkovic V, Segalés J, Nielsen J, Fomsgaard A, Darji A.
  • Infectious phage particles packaging antibiotic resistance genes found in meat products and chicken feces. Sci Rep. 2019 Sep 16;9(1):13281
    Gómez-Gómez C, Blanco-Picazo P, Brown-Jaque M, Quirós P, Rodríguez-Rubio L, Cerdà-Cuellar M, Muniesa M.
  • High prevalence and diversity of Extended-Spectrum β-Lactamase and emergence of OXA-48 producing Enterobacterales in wildlife in Catalonia. PLoS One. 2019 Aug 5;14(8):e0210686
    Darwich L, Vidal A, Seminati C, Albamonte A, Casado A, López F, Molina-López RA, Migura-Garcia L.
  • Association between the pig genome and its gut microbiota composition. Scientific Reports, 9(1):8791; doi: 10.1038/s41598-019-45066-6, 2019
    D Crespo-Piazuelo, L Migura-García, J Estellé, L Criado-Mesas, M Revilla, A Castelló, M Muñoz, JM. García-Casco, AI Fernández, M Ballester, and J M Folch.
  • Use of group records of feed intake to select for feed efficiency in rabbit. Journal of Animal Breeding and Genetics 2019: 1-10 DOI: 10.1111/jbg.12395
    Piles, M., and Sánchez J. P
  • Modulatory Effect of Protein and Carotene Dietary Levels on Pig gut Microbiota. Scientific Reports volume 9, Article number: 14582 (2019)
    R González-Prendes, R Natacha Pena, E Solé, A Reza Seradj, J Estany & Y Ramayo-Caldas
  • Integrating genome-wide co-association and gene expression to identify putative regulators and predictors of feed efficiency in pigs. Genetics Selection Evolution volume 51, Article number: 48 (2019)
    Y Ramayo-Caldas, E Mármol-Sánchez, M Ballester, J P Sánchez, R González-Prendes, M Amills & R Quintanilla.
  • Antimicrobial resistance profiles of Pasteurella multocida, Mannheimia haemolytica and Moraxella spp. of bovine origin pre- and post-treatment with antimicrobials in calves.
    Migura-Garcia, L.; Marti, S.; Aris, A.; Perez de Rozas, A.; Tejero, C.; Torra, J.; Pujols, J.; Devant, M.
  • Ontogeny of lymphoid organs and mucosal associated lymphoid tissues in meagre (Argyrosomus regius). Fish & Shellfish Immunology, 84: 509-520.
    C Campoverde, K B. Andree, DJ. Milne, A Estévez, E Gisbert, F Carella
  • Gene expression analysis of the innate immune system during early rearing and weaning of meagre (Argyrosomus regius). Fish & Shellfish Immunology,
    C Campoverde, D J. Milne, C J. Secombes, A Estevez, E Gisbert, K B. Andree
  • Urban wild boars and the zoonotic risk of Streptococcus suis. Emerging Infectious Diseases (2018) 24(6):1083-1086
    Fernández-Aguilar X, Gottschalk M, Aragon V, Càmara J, Ardanuy C, R Velarde, N Galofré-Milà, R Castillo-Contreras, JR López-Olvera, G Mentaberre, A Colom-Cadena, S Lavín, O Cabezón.
  • Limited interactions between Streptococcus suis and Haemophilus parasuis in in vitro co-infection studies. Pathogens (2018) 7(1). pii: E7
    Mathieu-Denoncourt A, C Letendre, J-P Auger, M Segura, V Aragon, S Lacouture, M Gottschalk.
  • Characterization of Bergeyella spp. isolated from the nasal cavities of piglets. Veterinary Journal (2018) 234:1-6
    Lorenzo de Arriba M, S Lopez-Serrano, N Galofre-Mila, V Aragon.
  • Comparison of cytokine profiles in peripheral blood mononuclear cells between piglets born from Porcine circovirus 2 vaccinated and non-vaccinated sows. Vet Microbiol. 2018, 214:148-153.
    Oliver-Ferrando S, Segalés J, Sibila M, Díaz I.
  • Exploratory field study on the effect of Porcine circovirus 2 (PCV2) sow vaccination on serological, virological and reproductive parameters in a PCV2 subclinically infected sow herd. BMC Vet Res. 2018, 14(1):130.
    Oliver-Ferrando S, Segalés J, López-Soria S, Callén A, Merdy O, Joisel F, Sibila M.
  • Protective effect of a polyvalent influenza DNA vaccine in pigs. Vet Immunol Immunopathol.2018. 195:25-32
    Karlsson I, Borggren M, Rosenstierne MW, Trebbien R, Williams JA, Vidal E, Vergara-Alert J, Foz DS, Darji A, Sisteré-Oró M, Segalés J, Nielsen J, Fomsgaard A.
  • Population Structure, Antimicrobial Resistance, and Virulence-Associated Genes in Campylobacter jejuni Isolated From Three Ecological Niches: Gastroenteritis Patients, Broilers, and Wild Birds. Front Microbiol. 2018 Aug 2;9:1676.
    Iglesias-Torrens Y, Miró E, Guirado P, Llovet T, Muñoz C, Cerdà-Cuéllar M, Madrid C, Balsalobre C, Navarro F.
  • Digestive microbiota is different in pigs receiving antimicrobials or a feed additive during the nursery period. PlosOne. 2018 May 25. 2018 May 25;13(5):e0197353
    Fraile L, T Goosens, A Bermejo, L Migura-Garcia, et al.
  • Characterization of Campylobacter jejuni and Campylobacter coli Broiler Isolates by Whole-Genome Sequencing. Foodborne Pathog Dis. 2018 Mar;15(3):145-152.
    Cantero G, Correa-Fiz F, Ronco T, Strube M, Cerdà-Cuéllar M, Pedersen K.
  • Multidrug resistant Salmonella isolated from conventional pig farms that use antimicrobial agents in their preventive medicine programmes Vet J. 234 (2018) 36–42
    Cameron-Veas C, Fraile L, Napp S, Garrido V, Grilló MJ and Migura-Garcia L.
  • Characterization of the bacterial microbiota composition along the intestinal tract in pigs, their interactions and functions. Scientific Reports, 8, 12727; 10.1038/s41598-018-30932-6, 2018
    D Crespo-Piazuelo, J Estellé, Ml Revilla, L Criado-Mesas, Y Ramayo-Caldas, C Óvilo, AI Fernández, M Ballester, and J M Folch
  • Rabbit Microbiota Changes Throughout the Intestinal Tract. Frontiers in Microbiology, 2018 9-2144
    Velasco-Galilea María, Piles Miriam, Viñas Marc, Rafel Oriol, González-Rodríguez Olga, Guivernau Miriam & Sánchez J. P.
  • Longitudinal analysis of direct and social effects on the average daily gain in rabbits. Genetics Selection Evolution 2018-50:25
    David I., Sánchez J. P., Piles M.
  • Integrative approach using liver and duodenum RNA-Seq data identifies candidate genes and pathways associated with feed efficiency in pigs. Scientific Reports volume 8, Article number: 558 (2018).
    Y Ramayo-Caldas, M Ballester, J P Sánchez, O González-Rodríguez, M Revilla, H Reyer, K Wimmers, D Torrallardona & R Quintanilla.
  • Diets containing shrimp protein hydrolysates provided protection to European sea bass (Dicentrarchus labrax) affected by an outbreak of Vibrio pelagius. Aquaculture, 495: 136-143.
    E Gisbert, V Fournier, M. Solovyev, A. Skalli, K B. Andree
  • Effect of B-Glucans in Diets on Growth, Survival, Digestive Enzyme Activity, and Immune System and Intestinal Barrier Gene Expression for Tropical Gar (Atractosteus tropicus) Juveniles. Fishes, 3 (27); doi:10.3390/fishes3030027.
    K N. Nieves-Rodríguez , C Alfonso Álvarez-González, E S. Peña-Marín, F Vega-Villasante, R Martínez-García, S Camarillo-Coop, D Tovar-Ramírez, L T. Guzmán-Villanueva, K B. Andree and E Gisbert
  • The discovery and comparative expression analysis of three distinct type I interferons in the perciform fish, meagre (Argyrosomus regius). Developmental and Comparative Immunology, 84: 123e132
    D.J. Milne, C. Campoverde, K.B. Andree, X. Chen, J. Zou, C.J. Secombes
  • A “pathotyping” multiplex PCR for Haemophilus parasuis: a tool for the prediction of virulence. J Clin Microbiol (2017) 55(9):2617-2628
    Howell K, L Weinert, S Peters, J Wang, J Hernandez-Garcia, R Chaudhuri, S-L Luan, O Angen, V Aragón, S Williamson, P Langford, A Rycroft, B Wren, D Maskell, and D Tucker.
  • A robust PCR for the differentiation of potential virulent strains of Haemophilus parasuis. BMC Veterinary Research (2017) 13(1):124
    Galofré-Milà N, F Correa-Fiz, S Lacouture, M Gottschalk, K Strutzberg-Minder, A Bensaid, S Pina-Pedrero, V Aragon.
  • Identification of a surface epitope specific of virulent strains of Haemophilus parasuis. Veterinary Microbiology (2017) 198:116–120
    Correa-Fiz F, N Galofre-Mila, M Costa-Hurtado, V Aragon.
  • A genetically engineered H5 protein expressed in insect cells confers protection against different clades of H5N1 highly pathogenic avian influenza viruses in chickens. Avian Pathol. 2017.  46(2):224-233.
    Oliveira Cavalcanti M, Vaughn E, Capua I, Cattoli G, Terregino C, Harder T, Grund C, Vega C, Robles F, Franco J, Darji A, Arafa AS, Mundt E.
  • How feeding calves pasteurized waste milk affects antimicrobial resistance phenotypes and genotypes of fecal Escherichia coli isolates before and after weaning. J Dairy Science. 2017 Jul 26. pii: S0022-0302(17)30708-7. 
    G Maynou, L Migura-Garcia,H.Chester-Jones, D.Ziegler, A. Bach, M.Terré.
  • Seabirds (Laridae) as a source of Campylobacter spp., Salmonella spp. and antimicrobial resistance in South Africa. Environ Microbiol. 2017 Oct;19(10):4164-4176.
    Moré E, Ayats T, Ryan PG, Naicker PR, Keddy KH, Gaglio D, Witteveen M, Cerdà-Cuéllar M.
  • How feeding calves pasteurized waste milk affects antimicrobial resistance phenotypes and genotypes of fecal Escherichia coli isolates before and after weaning. J Dairy Science. 2017 Jul 26. pii: S0022-0302(17)30708-7.
    G Maynou, L Migura-Garcia,H.Chester-Jones, D.Ziegler, A. Bach, M.Terré.
  • Antimicrobial resistance of Salmonella serovars and Campylobacter spp. isolated in an opportunistic gull species, Yellow-legged gull (Larus michahellis). J Wildl Dis. 53(1), 2017, pp. 148–152
    L Migura-Garcia R. Ramos, M. Cerdà-Cuéllar.
  • A production calendar based on water temperature, spat size and husbandry practices reduce OsHv-1 µvar impact on cultured pacific oyster Crassostrea gigas in the Ebro Delta (Catalonia), Mediterranean Coast of Spain. Frontiers in Physiology 8 (125): 1- 10.
    Carrasco, N., Gairín, I., Pérez, J., Andree, K.B., Roque, A., Fernández-Tejidor, M., Rodgers, C.J., Aguilera, C., Furones, M.D.
  • Ontogeny and modulation after PAMPs stimulation of b-defensin, hepcidin, and piscidin antimicrobial peptides in meagre (Argyrosomus regius). Fish & Shellfish Immunology, 69: 200-210.
    Cindy Campoverde, Douglas J. Milne, Alicia Estevez, Neil Duncan, Christopher J. Secombes, Karl B. Andree
  • Two types of TNFα in meagre (Argyrosomus regius): Discovery, distribution and expression modulation. Molecular Immunology, 92: 136–145.
    D. J. Milne, C. Campoverde, K.B. Andree, J. Zou, C.J. Secombes
  • Piglet nasal microbiota at weaning may influence the development of Glässer’s disease during the rearing period. BMC Genomics (2016) 17(1):404.
    Correa-Fiz F, L Fraile, V Aragon.
  • Enhanced antibacterial effect of antibiotics in combination with silver nanoparticles against animal pathogens. Veterinary Journal (2016) 209:174-9.
    Smekalova M, V Aragon, A Panacek, R Prucek, R Zboril, L Kvitek.
  • Effect of high and low maternally derived antibodies on porcine circovirus type 2 (PCV2) infection dynamics and production parameters in PCV2 vaccinated pigs under field conditions. Vaccine. 2016; 34 (27): 3044-50
    Feng H., J. Segalés, L. Fraile, S. López-Soria, M. Sibila.
  • Evaluation of natural porcine circovirus type 2 (PCV2) subclinical infection and seroconversion dynamics in piglets vaccinated at different ages. Vet Res. 2016; 47(1):121.
    Oliver-Ferrando S.; J. Segalés; S. López-Soria; A. Callén; O. Merdy; F. Joisel; Marina Sibila.
  • Multi-Level Analysis of vanA and vanB Enterococcus faecium Causing Nosocomial Outbreaks in 27 Countries (1986-2012): The Significance of Relatedness in the Epidemiology of Vancomycin Resistance. JAC. 2016 Dec;71(12):3351-3366.
    A Freitas, A Tedim, M Francia, L Jensen, C Novais, L Peixe, A Sánchez-Valenzuela, A Sundsfjord, K Hegstad, G Werner, E Sadowy, A Hammerum, L Garcia-Migura, et al.
  • Genetic diversity and antimicrobial resistance of Campylobacter and Salmonella strains isolated from decoys and raptors. Comp Immunol Microbiol Infect Dis. 2016 Oct;48:14-21
    Jurado-Tarifa E, Torralbo A, Borge C, Cerdà-Cuéllar M, Ayats T, Carbonero A, García-Bocanegra I.
  • Shedding of cephalosporin resistant Escherichia coli in pigs from conventional farms after early treatment with antimicrobials. Vet J. 211 (2016) 21–25
    K Cameron-Veas, MA Moreno, L Fraile, L Migura-Garcia.
  • Vitamin A supplementation enhances Senegalese sole (Solea senegalensis) early juvenile’s immunocompetence: New insights on potential underlying pathways. Fish & Shell. Imm. 46: 703-709.
    I Fernandez, C Lopez-Joven, K B. Andree, A Roque, E Gisbert



Linked scientific projects:


>> Click here and all related projects will be displayed, with title and main contact:


  • The regulatory GENomE of SWine and CHicken: functional annotation during development (GENE-SWitCH).
    Contact: Maria Ballester
  • Genetic determination of immunological capacity in pigs: identification of functional genetic variants for the implementation of genomic selection (IMMUPIGEN)
    Contact: Maria Ballester
  • Gut microbiota and host genetics: joint contribution to efficiency, behavior and robustness in pigs (PIGBIOTA)
    Contact: Yuliaxis Ramayo-Caldas, Antoni Dalmau
  • HEALTHY_SNPIG: A pilot Open-Array project for genotyping potential causal mutations for immunity traits in pigs.
    Contact: Maria Ballester
  • GENEF: Improved feed efficiency in pigs and rabbits. Genetic determinism and selection strategies
    Contact: Juan Pablo Sánchez, Miriam Piles
  • GENEF2: Improvement of the effectiveness and viability of genetic selection programs to increase the feeding efficiency of prolific species
    Contact: Miriam Piles, Juan Pablo Sánchez
  • Impact of the reduction of the use of antibiotics in poultry farming on the presence of resistant Campylobacter spp
    Contact: Marta Cerdà
  • CAMPYBIO: Understanding host-pathogen interactions of Campylobacter infection in broilers in order to design targeted control strategies in poultry production.
    Contact: Marta Cerdà, Miquel Nofrarías
  • Optimization of diagnosis and treatment of post-weaning diarrheas in pigs: towards a rational use of antibiotics (RTI2018-095586-B-C22)
    Contact: Lourdes Migura/Laila Darwich
  • Antimicrobial susceptibility test as a tool for antimicrobial stewardship in fattening cattle.
    Contact: Lourdes Migura
  • Kit point of care for the detection of resistant bacteria (RES-KIT)
    Contact: Lourdes Migura
  • FunIbiota. Nasal microbiota functionality and effect on the immune response of piglets (FunIBiota)
    Contact: Virginia Aragón/Flor Correa
  • Program for Innovative Global Prevention of Streptococcus suis (PIGSs)
    Contact: Virginia Aragón
  • ITN INNOTARGETS: INNOvative approaches to identification of metabolic TARGETS for antimicrobials
    Contact: Virginia Aragón
  • Strategies to mitigate risk and biomarkers in the new paradigm of health and welfare of lactating calves – SAFECALF (PID2019-104021RB-I00) 
    Contact: Maria Devant / Sònia Martí
  • Production and validation of drugs based on host defense peptides for the treatment of Bovine Respiratory Syndrome – WEWINBRD (PID2019-107298RB-C21)
    Contact: Anna Arís /Elena Garcia
  • Prevention of vascular catheter-related infections by the FUNctionalization of CATHeters with thermically activated hydrogels with antimicrobial agents of broad spectrum (FUNCATH).
    Contact: Elena Garcia
  • Who and What
    Contact: Maria Devant
  • Instauració de protocols de treball per reduir l’ús d’antibiòtics en granges de boví lleter
    Contact: Marta Terré
  • Validation of the use of the proteins M-SAA3 and MMP-9 in the improvement of the dairy cow drying and optimization of its effective dose by means of its nanostructuring – RTA2015-00064-C02.
    Contact: Elena Garcia
  • IRTA cutting edge Project: Development of a novel recombinant platform for the production of antimicrobial nanoparticles: the first step in the fight against bacterial infections
    Contact: Anna Arís /Elena Garcia
  • Environmental Spread and Persistence of Antibiotic REsistances in aquatic Systems Exposed to oyster Aquaculture (SPARE-SEA)
    Contact: Karl Andree
  • MedAID
    Contact: Dolors Furones
  • NewTechAqua
    Contact: Enric Gisbert
  • LIFE SPOT:  Green solutions for treating groundwater pollution to meet drinking water directive standards – LIFE18 ENV/ES/000199
    Contact: Marc Viñas
  • LIFE AGRICLOSE: Improvement and disclosure of efficient techniques for manure management towards a circular and sustainable agriculture.
    Contact: August Bonmatí, Assumpció Antón
  • DECIDE: Data-driven control and prioritisation of non-EU-regulated contagious animal diseases
    Contact: Joaquim Segales, Marina Sibila, Toni Velarde
  • Estrategies to prent posweaning diarrhea in pigs of organic farming
    Contact: Emma Fabregas
  • BROILERNET – Practice and Science Broiler Production Innovation Network
    Contact: Natalia Majo
  • European Union Reference Centre for Animal Welfare for Poultry and other small farmed animals (EURCAW-Poultry-SFA-2020).
    Contact: Antonio Velarde
  • Deciphering Campylobacter coli-host interactions for the development of effective control tools in poultry farming (COLIBIO)
    Contact: Marta Cerda/Miquel Nofrarias
  • Synergistic strategies as biocontrol tools to reduce the use of antimicrobials, and minimize the spread of enteropathogens from swine farm to fork; a One Health approach (FAECAL-PHAGE)
    Contact: Lourdes Migura
  • Systems biology understanding of pathways and genes involved in immunometabolism: towards the joint improvement of immunocompetence and production efficiency in swine (METAPIGEN).
    Contact: Maria Ballester/Raquel Quintanilla
  • Study of the interrelations between the gut microbiota and animal behaviour (intestine-brain axis) in fattening pigs
    Contact: Yuliaxis Ramayo/Toni Dalmau
  • HoloRuminant: Understanding microbiomes of the ruminant holobiont
    Contact: Yuliaxis Ramayos
  • Holistic solution to improve animal food production through deconstructing the biomolecular interactions between feed, gut microorganisms and animals in relation to performance parameters
    Contact: Joan Tarradas
  • Assessment of the immunomodulatory effects induced by probiotic strains (as an alternative to antibiotics) on the regulatory mechanisms of inflammation and tolerance in birds (IMMUNO-FEED)
    Contact: J. Tarradas
  • KapPA: Cap a la desmedicalització del Porcí mitjançant estratègies nutricionals Alternatives a antibiòtics/antimicrobians.
    Contact: Joan Tarradas
  • GO ATENEAA: Aplicació proteïna d´insecte (TENEbrio molitor) per Alimentació animal i del frass per a Agricultura orgànica.
    Contact: Núria Tous
  • Projecte demostratiu LEAKYGUT
    Contact: Maria Devant / Sònia Martí
  • Estudi de la llet de Transició per a millorar . Projecte demostratiu Transimilk
    Contact: Anna Arís /Elena Garcia
  • Noves molècules antimicrobianes basades en HDPs per tractar el síndrome respiratori boví (Vetpharma)
    Contact: Anna Arís /Elena Garcia

Revisa aquest camp

Revisa aquest camp

Revisa aquest camp

Your message has been sent succesfully
Unable to send, try again