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Joan Cerdà

POSITION: Senior Research Scientist - Director of the Emergent Group of Comparative Molecular Physiology
PHONE 93 230 95 31

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Professional information:

Dr. Joan Cerdà (1965, Barcelona, Spain) obtained the B.Sc. in Biology (Zoology and Physiology) in 1988 by the University of Navarra (Pamplona, Spain) and the PhD in Physiology and Biochemistry in 1993 by the University of Barcelona (Spain). In 1994, he moved to the Whitney Laboratory for Marine Bioscience (University of Florida, USA) as a postdoctoral researcher with a fellowship from the Spanish Ministry of Education and Science. In 1996, he joined the German Cancer Research Center (Heidelberg, Germany) as a Marie Curie postdoctoral fellow (European Commission). In 1999, Dr. Cerdà became Research Scientist at the Institut de Recerca i Tecnologia Agroalimentàries (IRTA), where he is now Senior Research Scientist A (Prof. level) director of the Emergent Group of Comparative Molecular Physiology located at the Institute of Marine Sciences from the Spanish National Research Council (CSIC) in Barcelona. Dr. Cerdà has more than 25 years of research experience on fish reproductive biology and has been the principal investigator/coordinator of 17 national and international research projects. The current research interest focuses on the molecular basis of gamete (germ cell) formation and function towards the development of biotechnological inventions for animal production and conservation biology. Present research lines include: 1) Comparative studies on the evolution, structure and function of aquaporins. 2) Molecular physiology of aquaporins and ion channels in female and male gametes. 3) Development of new biotechnological methods based on aquaporins for cell preservation. 4) Molecular endocrinology of spermiogenesis. Dr. Cerdà has published 103 SCI papers, and he is author of more than 90 presentations in meetings, several book chapters, and edited two books.  He has supervised 7 PhD thesis and several postdoctoral researchers. Since 2005, Dr. Cerdà’s research group holds the “Consolidated Research Group” mention given by the Government of Catalonia. Dr. Cerdà is a regular referee for different international scientific journals, and serves in the editorial board of Molecular Genetics and Genomics (Springer), The Biological Bulletin (The University of Chicago Press), Scientific Reports (Springer Nature), and The Open Reproductive Science Journal (Bentham Science Publishers Ltd.).

 

Current projects

 

Development of aquaporin-based molecular markers of gamete quality for marine fish aquaculture (AQUAMARK). Spanish Ministry of Economy and Competitiveness, Ministry of research, development and innovation. Ref.: AGL2013-41196-R. PI: J. Cerdà. Participants: F. Chauvigné and R. N. Finn (Univ. Bergen, Norway), B. Norberg (Institute of Marine Research, Norway), L. Bargelloni (Univ. Padova, Italy). Dates: 01/01/2014-31/12/2016.

The molecular physiology of aquaporin-related cataract in farmed Atlantic salmon (AQUALENS). Norwegian Research Council, Havbruk Program, Ref.: ES498499. PI: R.N. Finn (UoB, Norway). Participants: J. Cerdà (IRTA, Spain), G.-L. Taranger, P.G. Fjelldal, T. Hansen (IMR, Norway), R. Waagbø (NIFES, Norway). Dates: 01/04/2013-31/03/2016.

Water and ion channels as novel antioxidant and kinetic markers of sperm quality in marine teleosts (SPERMIOPORIN). Spanish Ministry of Economy and Competitiveness. Ref.: AGL2016-76802-R. PI: J. Cerdà. Participants: P. M. T. Deeen and J. van der Wijst (Radboud University Medical Center, Netherlands), F. Chauvigné and R. N. Finn (Univ. Bergen, Norway). Dates: 01/01/2017-31/12/19.

Immunosuppression of aquaglyceroporins in salmon lice (IMMUNOPORIN). Norwegian Research Council, Havbruk Program, Ref.: 254872/E40. PI: R.N. Finn (UoB, Norway). Participants: J. Cerdà (IRTA, Spain), F. Nielsen (SLRC, UoB, Norway), P.G. Fjelldal (IMR, Norway), Ivar Hordvik (UoB, Norway). Dates: 01/01/2016-31/12/2019.

 

Highlighted publications

 

Chauvigné F., Ollé J., González W., Duncan N., Giménez I., Cerdà J. (2017) Toward developing recombinant gonadotropin-based hormone therapies for increasing fertility in the flatfish Senegalese sole. PLoS One 12(3):e0174387. 

Cerdà J., Chauvigné F., Finn R.N. (2017) The physiological role and regulation of aquaporins in teleost germ cells. Advances in Experimental Medicine and Biology 969:149-171.

Eskova A., Chauvigné F., Maischein H.-M., Ammelburg M., Cerdà J., Nüsslein-Volhard C., Irion U. (2017) Gain-of-function mutations in Aqp3a influence zebrafish pigment pattern formation through the tissue environment. Development144:2059-2069.

Bedford-Guaus SJ., Chauvigné F., Mejía-Ramírez E., Martí-Gaudes M., Ventura A., Raya A., Cerdà J.*, Veiga A.* (2016) Expression of the T85A mutant of zebrafish aquaporin 3b improves post-thaw survival of cryopreserved early mammalian embryos. Zygote 24: 839-847 (*, corresponding authors).

Chauvigné F., Verdura A., Mazón M.J., Boj M., Zanuy S., Gómez A., Cerdà J. (2015) Development of a flatfish-specific enzyme-linked immunosorbent assay for Fsh using a recombinant chimeric gonadotropin. General and Comparative Endocrinology 221:75-85.

Boj M., Chauvigné F., Cerdà J. (2015) Aquaporin biology of spermatogenesis and sperm physiology in mammals and teleosts. Biological Bulletin 229:93-108. 

Finn R.N., Cerdà J. (2015) Evolution and functional diversity of aquaporins. Biological Bulletin 229:6-23. 

Boj M., Chauvigné F., Cerdà J. (2015) Coordinated action of aquaporins regulates sperm motility in a marine teleost. Biology of Reproduction 93(2):40, 1-11. 

Finn R.N., Chauvigné F., Stavang J.A., Bellés X., Cerdà J. (2015) Insect glycerol transporters evolved by functional co-option and gene replacement. Nature Communications 6:7814.

Chauvigné F., Zapater C., Stavang J.A., Taranger G.L., Cerdà J.*, Finn R.N.* (2015) The pH sensitivity of Aqp0 channels in tetraploid and diploid teleosts. FASEB Journal 29:2172-2184 (*, corresponding authors).

Chauvigné F., Boj M., Finn R.N., Cerdà J. (2015) Mitochondrial aquaporin-8-mediated hydrogen peroxide transport is essential for teleost spermatozoon motility. Scientific Reports 5:7789. 

Finn R.N, Chauvigné F., Hlidberg J.B., Cutler C.P., Cerdà J. (2014) The lineage-specific evolution of aquaporin gene clusters facilitated tetrapod terrestrial adaptation. PLoS One 9(11):e113686. 

Chauvigné F., Zapater C., Crespo D., Planas J.V., Cerdà J. (2014) Fsh and Lh direct conserved and specific pathways during flatfish semicystic spermatogenesis. Journal of Molecular Endocrinology 53:175-190. 

Kanagaraj P., Gautier-Stein A., Riedel D., Schomburg C., Cerdà J., Vollack N., Dosch R. (2014) Souffle/Spastizin controls secretory vesicle maturation during zebrafish oogenesis. PLoS Genetics 10(6):e1004449. 

Morató R., Chauvigné F., Novo S., Bonet S., Cerdà J. (2014) Enhanced water and cryoprotectant permeability of porcine oocytes after artificial expression of human and zebrafish aquaporin-3 channels. Molecular Reproduction and Development 81:450-461. 

Chauvigné F., Zapater C., Gasol J.M., Cerdà J. (2014) Germ line activation of the luteinizing hormone receptor directly drives spermiogenesis in a non-mammalian vertebrate. Proceedings of the National Academy of Sciences USA 111:1427-1432. 

Chauvigné F., Boj M., Vilella S., Finn R.N., Cerdà J. (2013) Subcellular localization of selectively permeable aquaporins in the male germ line of a marine teleost reveals spatial redistribution in activated spermatozoa. Biology of Reproduction 89(2):37, 1-17 (Commentary: 89(2): 36, 1-2).

Zapater C., Chauvigné F., Tingaud-Sequeira A., Finn R.N., Cerdà J. (2013) Primary oocyte transcriptional activation of aqp1ab by the nuclear progestin receptor determines the pelagic egg phenotype of marine teleosts. Developmental Biology 377:345-362. 

Seeliger D., Zapater C., Krenc D., Haddoub R., Flitsch S., Beitz E., Cerdà J.*, de Groot B.L.* (2013) Discovery of novel human aquaporin-1 blockers. ACS Chemical Biology 8:249-256 (*, corresponding authors). 

Chauvigné F., Verdura S., Mazón M.J., Duncan N., Zanuy S., Gómez A., Cerdà J. (2012) Follicle-stimulating hormone and luteinizing hormone mediate the androgenic pathway in Leydig cells of an evolutionary advanced teleost. Biology of Reproduction 87(2):35,1-11. 

Zapater C., Chauvigné F., Norberg B., Finn R.N., Cerdà J. (2011) Dual neofunctionalization of a rapidly evolving aquaporin-1 paralog resulted in constrained and relaxed traits controlling channel function during meiosis resumption in teleosts. Molecular Biology and Evolution 28:3151-3169. 

Finn R.N., Cerdà J. (2011) Aquaporin evolution in fishes. Frontiers in Physiology 2:44. 

Chauvigné F., Lubzens E., Cerdà J. (2011) Design and characterization of genetically engineered zebrafish aquaporin-3 mutants highly permeable to the cryoprotectant ethylene glycol. BMC Biotechnology 11:34. 

Cerdà J., Finn R.N. (2010) Piscine aquaporins: an overview of recent advances. Journal of Experimental Zoology Part A: Ecological Genetics and Physiology 313A:623-650. 

Chauvigné F., Tingaud-Sequeira A., Agulleiro M.J., Calusinska M., Gómez A., Finn R.N., Cerdà J. (2010) Functional and evolutionary analysis of flatfish gonadotropin receptors reveals cladal- and lineage-level divergence of the teleost glycoprotein receptor family. Biology of Reproduction 82:1088-1102. 

Forné I., Abián J., Cerdà J. (2010) Fish proteome analysis: model organisms and non-sequenced species. Proteomics 10:858-872. 

Tingaud-Sequeira A., Calusinska M., Finn R.N., Chauvigné F., Lozano J., Cerdà J. (2010) The zebrafish genome encodes the largest vertebrate repertoire of functional aquaporins with dual paralogy and substrate specificities similar to mammals. BMC Evolutionary Biology 10:38. 

Lubzens E., Young G., Bobe J., Cerdà J. (2010) Oogenesis in teleosts: how fish eggs are formed. General and Comparative Endocrinology 165:367-389. 

Cerdà J., Mercadé J., Lozano J.J., Manchado M., Tingaud-Sequeira A., Astola A., Infante C., Halm S., Viñas J., Castellana B., Asensio E., Cañavate P., Martínez-Rodríguez G., Piferrer F., Planas J.V., Prat F., Yúfera M., Durany O., Subirada F., Rosell E., Maes T. (2008) Genomic resources for a commercial flatfish, the Senegalese sole (Solea senegalensis): EST sequencing, oligo microarray design, and development of the bioinformatic platform Soleamold. BMC Genomics 9:508. 

Fabra M., Raldúa D., Bozzo M.G., Deen P.M.T., Lubzens E., Cerdà J. (2006) Yolk proteolysis and aquaporin-1o play essential roles to regulate fish oocyte hydration during meiosis resumption. Developmental Biology 295:250-262. 

Fabra M., Raldúa D., Power D.M., Deen P.M.T., Cerdà J. (2005) Marine fish egg hydration is aquaporin-mediated. Science 307:545.